Michael Thomas CLANDININ,John MIKLAVCIC,Vera MAZURAK
申请号：
US13250167
公开号：
US20120083459A1
申请日:
2011.09.30
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Uses of exogenous ganglioside to inhibit the propagation of prostate cancer cells are provided. Gangliosides regulate many cellular processes including cell death. The present disclosure assesses the role of ganglioside in prostate cell growth. Malignant prostate (PC-3) and control (RWPE-1) cells can be cultured with or without ganglioside treatment. Cells can be assayed for differences in cell growth. Supplementation with ganglioside (GD3) can decrease growth of PC-3 cells by 30% compared to controls (p<0.01). Ganglioside can have therapeutic benefit in prostate cancer as demonstrated by decreased growth of malignant PC-3 cells.
