Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents本發明提供化合物、組成物及用於治療黃病毒科(Flaviviridae)感染(包括HCV感染)之方法。在某些實施態樣中,本發明揭示核苷衍生物之化合物及組成物,彼等可被單獨投予或與其他抗病毒劑組合投予。