Provided herein are compounds, compositions and methods for the treatment of liver disorders, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.本發明提出用於治療肝病(包括HCV感染)之化合物、組成物與方法。某些具體實施例揭露核苷衍生物之化合物與組成物,其可單獨投藥或聯合其他抗病毒藥劑投藥。