An physiological processing device is provided in the disclosure. The physiological processing device comprises a patch, a plurality of electrodes and a processing device. The plurality of electrodes detects an ECG signal. The processing device is configured in the patch and is coupled the plurality of electrodes to receive the ECG signal. In addition, the processing device calculates a first differential value of the voltage values of the R waves of the ECG signal and a reference ECG value, and determines whether the first differential value is larger than or equal to a first threshold value to determine whether adjust the positions of the plurality of electrodes. When the positions of the plurality of electrodes are confirmed, the processing device obtains the heartbeat information and/or the breathing information.本揭露提供了一種生理信號處理裝置。上述生理信號處理裝置包括一貼片本體、複數電極，以及一處理裝置。複數電極會偵測一心電信號。處理裝置配置於貼片本體，且耦接複數電極，以接收心電信號。此外，處理裝置根據心電信號，計算心電信號之R波之電壓值和一心電信號基準值之一第一差值，並判斷第一差值是否大於或等於一第一臨界值，以決定是否需要調整複數電極之位置。當複數電極之位置確定後，處理裝置根據心電信號，取得一心跳資訊以及/或一呼吸資訊。
