Devices, systems, and methods for visually depicting a vessel and evaluating risk associated with a condition of the vessel are disclosed. In one embodiment, a method of evaluating a vessel of a patient includes obtaining physiology measurements from a first instrument and a second instrument positioned within the vessel of the patient while the second instrument is moved longitudinally through the vessel from a first position to a second position and the first instrument remains stationary within the vessel outputting the physiology measurements and an image of the vessel on a display, the output image including visualizations based on the obtained physiology measurements and evaluating whether to perform to surgical procedure based on the physiology measurements and the image of the vessel.
