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Nucleic Acid Vaccines for Varicella zoster virus (VZV) z\u00d3ster
专利权人:
MODERNATX; INC.
发明人:
申请号:
ARP160103246
公开号:
AR106463A1
申请日:
2016.10.24
申请国别(地区):
AR
年份:
2018
代理人:
摘要:
Claim 1: vaccination of Varicella zoster virus (VZV) comprising at least one polinucle\u00f3tido RNA has an open reading frame encoding a polypeptide Antigen of at leastVZV and a pharmaceutically acceptable carrier or excipient.27: The VZV Vaccine claims of any of claims 1 - 3 where the at least one polinucle\u00f3tido RNA is encoded by a Nucleic Acid Sequence,At least a portion of a Nucleic Acid Sequence or at least an epitope of a selected Nucleic Acid Sequence of SEQ ID no. 1 - 8, 37, 39, 41, 60, 62, 64, 66, 68, 70, 72, 74, 76, 78,80, 82, 84, 86, 88, 90, or where the at least one polinucle\u00f3tido RNA is encoded by a Nucleic Acid Sequence,At least a portion of a Nucleic Acid Sequence or a sequence of an epitope of a selected Nucleic Acid Sequence of SEQ ID no. 6, 37, 39, 84 or 85.Claim 61: the use of a VZV vaccine of any of claims 1 - 59 for the manufacture of a Medicament for use in a method for Inducing an immune response in ESPEcifica to antigens in a subject comprising Administering the vaccine to the subject in an amount effective to produce an immune response to specific antigens.Claim 62: a method to prevent or treat VZV infection comprising administering to a subject the vaccine of any of claims 1 - 59.Claim 87: a genetically modified Nucleic Acid coding for at least one polinucle\u00f3tido RNA vaccine of any of claims 1 - 59.88: a Vindication of VZV Vaccine comprising at least one polinucle\u00f3tido ribonucleic acid (RNA), where the polinucle\u00f3tido RNA has (i) a socket Terminal 5 ,(ii) an open reading frame encoding at least one polypeptide Antigen of RSV and (iii) a 3 Polya tail.Reivindicación 1: Una vacuna del virus varicela-zóster (VZV) que comprende al menos un polinucleótido de ARN que tiene un marco de lectura abierto codificante de al menos un polipéptido antigénico de VZV y un portador o excipiente farmacéuticamente aceptable. Reivindicación 27: La vacuna de VZV de cualquiera de las reivindicaciones 1 - 3 en donde el al menos un polinucleó
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