Nicholas Brian Raffaele;Qun Dang;Feng Tian;Brett C. Bookser;Wenyu Li;Mark D. Erion;G. Sridhar Prasad
发明人:
Feng Tian,Qun Dang,G. Sridhar Prasad,Wenyu Li,Brett C. Bookser,Nicholas Brian Raffaele,Mark D. Erion
申请号：
US13115647
公开号：
US08940927B2
申请日:
2011.05.25
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention provides for novel compounds of Formulas I and II and pharmaceutically acceptable salts and co-crystals thereof which have glucokinase activator activity. The present invention further provides for pharmaceutical compositions comprising the same as well as methods of treating, preventing, delaying the time to onset or reducing the risk for the development or progression of a disease or condition for which one or more glucokinase activator is indicated, including Type 1 and 2 diabetes, impaired glucose tolerance, insulin resistance and hyperglycemia. The present invention also provides for processes of making the compounds of Formulas I and II, including salts and co-crystals thereof, and pharmaceutical compositions comprising the same.
