PURPOSE: A composition containing a Chrysanthemum zawadskii extract for preventing and treating cardiovascular diseases is provided to suppress damages to vascular endothelial cells, and to promote recovery of damaged endothelial cells. CONSTITUTION: A composition for preventing and treating cardiovascular diseases contains 0.1-50wt% of Chrysanthemum zawadskii extract based on a solid. The composition activates proliferation of vascular endothelial cells, and promotes recovery vascular endothelial cells. The extract is prepared from dried Chrysanthemum zawadskii with water or C1-C4 alcohol. The C1-C4 alcohol is ethanol. The extract enhances expression of one or more genes among SOD-2, SOD-3, and GPX-4. [Reference numerals] (AA) dRib 20mM + Chrysanthemum zawadskii extract； (BB) Chrysanthemum zawadskii content(mg/ml)본 발명은 구절초 추출물을 포함하는 심혈관계 질환의 예방 및 치료용 조성물에 대한 것이다. 본 발명에 따른 구절초 추출물을 포함하는 조성물은 혈관내피세포의 손상을 억제하고 손상된 혈관내피세포의 회복을 촉진하는 작용을 할 수 있다.
