ARASAPPAN, ASHOK,亚拉莎潘 阿夏克,亞拉莎潘 阿夏克,NJOROGE, F. GEORGE,恩裘洛吉 F 乔治,恩裘洛吉 F 喬治,BENNETT, FRANK,班奈特 法兰克,班奈特 法蘭克,GIRIJAVALLABHAN, VINAY M.,吉瑞加瓦拉邦 维纳M,吉瑞加瓦拉邦 維納M,HUANG, YUHUA,黄育华,黃育華,HUELGAS, REGINA,胡拉格斯 瑞吉内,胡
申请号：
TW098127908
公开号：
TWI409265B
申请日:
2009.08.19
申请国别(地区):
TW
年份:
2013
代理人:
摘要：
The present invention provides compounds of Formula (I):and tautomers, isomers, and esters of said compounds, and pharmaceutically acceptable salts, solvates, and prodrugs of said compounds, wherein wherein each of R, R1, X, Y, Z, R2, R3, R4, R5, R6, R7, R8, R9, R18, R19and n is selected independently and as defined herein. Compositions comprising such compounds are also provided. The compounds of the invention are effective as inhibitors of HCV, and are useful, alone and together with other therapeutic agents, in treating or preventing dieases or disorders such as viral infections and virus-related disorders.本發明提供一種式(I)化合物:及該等化合物之互變異構體、異構體及酯,及該等化合物之醫藥學上可接受之鹽、溶劑合物及前藥,其中R、R1、X、Y、Z、R2、R3、R4、R5、R6、R7、R8、R9、R18、R19及n各經獨立地選擇且如本文所定義。亦提供包含該等化合物之組合物。本發明之化合物有效作為HCV之抑制劑且單獨及與其他治療劑一起適用於治療或預防疾病或病症,諸如病毒感染及病毒相關病症。
