TECHNOPHAGE; INVESTIGAÇÃO E DESENVOLVIMENTO EM BIOTECNOLOGIA; S.A.
发明人:
Sofia VOLKER CÔRTE-REAL,Vera Luísa SANTOS NEVES,Pedro Manuel CORREIA CANHÃO,Tiago FLEMING OUTEIRO,Miguel Augusto RICO BOTAS CASTANHO,Frederico Nuno CASTANHEIRA AIRES DA SILVA,Soraia Rafaela SANTIAGO D
申请号：
US15545399
公开号：
US20180009883A1
申请日:
2016.01.29
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to antibody molecules and peptide delivery systems for use in the treatment and management of Alzheimer's disease and related disorders. In particular, the antibody molecules preferentially bind oligomeric forms of beta-amyloid peptide, in single domain format, and the peptide delivery systems facilitate specific transport of such antibody molecules, as well as other cargo molecules, across the blood-brain barrier. The invention also relates to constructs of the antibody molecules and the delivery peptides, as well as pharmaceutical compositions comprising effective amounts of the antibody molecules, delivery peptides, and/or their constructs, including humanized versions of the antibody molecules and constructs. The invention further relates to methods of making these products and pharmaceutical compositions thereof； and methods of using the pharmaceutical compositions in treating or preventing Alzheimer's and related disorders, such as those involving accumulation of beta-amyloid peptide or other peptides that aggregate in the brain； as well as to methods and kits for diagnosing these disorders.
