Technophage; investigacao e desenvolvimento em biotecnologia SA
发明人:
Volker Corte-Real, Sofia,Santos Neves, Vera Luisa,Correia Canhao, Pedro Manuel,Fleming Outeiro, Tiago,Rico Botas Castanho, Miguel Augusto,Castanheira Aires Da Silva, Frederico Nuno,Santiago De Oliveir
申请号：
AU2016210835
公开号：
AU2016210835A1
申请日:
2016.01.29
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
The present invention relates to antibody molecules and peptide delivery systems for use in the treatment and management of Alzheimer's disease and related disorders. In particular, the antibody molecules preferentially bind oligomeric forms of beta- amyloid peptide, in single domain format, and the peptide delivery systems facilitate specific transport of such antibody molecules, as well as other cargo molecules, across the blood-brain barrier. The invention also relates to constructs of the antibody molecules and the delivery peptides, as well as pharmaceutical compositions comprising effective amounts of the antibody molecules, delivery peptides, and/or their constructs, including humanized versions of the antibody molecules and constructs. The invention further relates to methods of making these products and pharmaceutical compositions thereof； and methods of using the pharmaceutical compositions in treating or preventing Alzheimer's and related disorders, such as those involving accumulation of beta-amyloid peptide or other peptides that aggregate in the brain； as well as to methods and kits for diagnosing these disorders.
