The subject invention provides pharmaceutical compositions containing laquinimod or a pharmaceutically acceptable salt thereof, an isolated compound of N-ethyl-4-hydroxyl-1-methyl-5-(methyl(2, 3, 4, 5, 6-pentahydroxyhexyl)amino)-2-oxo-N-phenyl-1, 2-dihydroquinoline-3-carboxamide or a salt thereof, compositions containing N-ethyl-4-hydroxyl-1-methyl-5-(methyl(2, 3, 4, 5, 6-pentahydroxyhexyl)amino)-2-oxo-N-phenyl-1, 2-dihydroquinoline-3-carboxamide and methods of preparing the same.本發明提供包含拉喹莫德(laquinimod)或其醫藥上可接受的鹽之醫藥組合物;分離化合物N-乙基-4-羥基-1-甲基-5-(甲基(2,3,4,5,6-五羥基己基)胺基)-2-側氧-N-苯基-1,2-二氫喹啉-3-甲醯胺或其鹽;包含N-乙基-4-羥基-1-甲基-5-(甲基(2,3,4,5,6-五羥基己基)胺基)-2-側氧-N-苯基-1,2-二氫喹啉-3-甲醯胺之組合物及其製備方法。
