A method for the preparation of an at least partly film-coated calcium-containing compound, wherein the calcium-containing compound is in the form of particles and/or crystals, the method comprising applying a coating composition comprising i) one or more water-soluble substances selected from the group consisting of polyols and carbohydrates and ii) one or more polymeric substances selected from the group consisting of povidones and copovidone to the calcium-containing compound, and the water-soluble substance and the polymeric substance is dispersed or dissolved in a solvent.本發明係關於已用水溶性物質及水溶性聚合物質至少部分地被覆薄膜及/或粒化之含鈣化合物，及該等經塗覆化合物在醫藥組合物中之用途。已證明該等至少部分地被覆薄膜及/或粒狀之含鈣化合物適於製備具有極高元素鈣負荷及便利地小尺寸之錠劑。在本發明之具有足夠機械及感官性能特性之錠劑中可獲得約96%或更多之藥物負荷。
