This invention the defeat/miss blood characteristic shock and the bleeding characteristic shock which designate teopederin derivative (Theopederin derivatives) chemical compound as the active ingredient, the riumachi characteristic arthritis and the bone arthritis, the inflammation characteristic intestinal disease, is the medicine study composition and the health food composition for preventing or remedy the immunity and the autoimmune disease and arteriosclerosis and like 2nd type diabetes the metabolism characteristic disease etc like the multiple sclerosis and something regarding the active inhibiter composition of the induction type one nitrogen oxide synthetic enzyme (iNOS). The composition by this invention obstructing the activity of the induction type one nitrogen oxide synthetic enzyme, (iNOS) is useful in remedy and prevention of the immunity disease and the metabolism characteristic disease by controlling the formation of one nitrogen oxide of the excessive quantity.本発明はテオペデリン誘導体(Theopederin derivatives)化合物を有効成分とする敗血性ショック、出血性ショック、リウマチ性関節炎、骨関節炎、炎症性腸疾患、多発性硬化症のような免疫及び自己免疫疾患と、動脈硬化、第2型糖尿病のような代謝性疾患などの予防又は治療のための薬剤学的組成物及び健康食品組成物と誘導型一酸化窒素合成酵素(iNOS)の活性阻害剤組成物に関するものである。本発明による組成物は誘導型一酸化窒素合成酵素(iNOS)の活性を阻害して過度な量の一酸化窒素の生成を抑制することによって免疫疾患及び代謝性疾患の治療及び予防に有用である。
