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5-Hydroxy-4- (trifluoromethyl) pyrazolopyridine derivatives
专利权人:
Daiichi Sankyo Company; Limited
发明人:
KOBAYASHI, Hideki,ARAI, Masami,KANEKO, Toshio,TERASAKA, Naoki
申请号:
ES14869320
公开号:
ES2671377T3
申请日:
2014.12.12
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
A compound represented by the general formula (I) ** Formula ** or a pharmacologically acceptable salt thereof: in which R represents an optionally substituted aryl group (the substituent or substituents is 1 to 3 identical or different groups selected from the group consisting of a halogen atom, a C1-6 alkyl group, a C3-7 cycloalkyl group, a trifluoromethyl group, a difluoromethoxy group, a trifluoromethoxy group, a cyano group, a C1-6 alkoxy group, a C3 cycloalkoxy group -7, a phenyl group, a C2-7 alkoxycarbonyl group, a benzyloxycarbonyl group, a di (C1-6 alkyl) aminocarbonyl group and a di (C1-6 alkyl) amino) group or an optionally substituted heteroaryl group (the heteroaryl is a 5 or 6 membered ring; the heteroatom or heteroatoms in the ring of the heteroaryl group is 1 or 2 nitrogen atoms, and in addition, the ring optionally contains a nitrogen atom, an oxygen atom or a sulfur atom; and the substituent or Substituents are 1 or 2 identical or different groups selected from the group consisting of a halogen atom, a C1-6 alkyl group, a C3-7 cycloalkyl group, a trifluoromethyl group, a difluoromethoxy group, a trifluoromethoxy group, a cyano group , a C1-6 alkoxy group, a C3-7 cycloalkoxy group, a phenyl group, a C2-7 alkoxycarbonyl group, a benzyloxycarbonyl group, a di (C1-6 alkyl) aminocarbonyl group and a di (C1-6 alkyl) group amino) and R1 represents a hydrogen atom or a hydroxy group.Un compuesto representado por la fórmula general (I) **Fórmula** o una sal farmacológicamente aceptable del mismo: en la que R representa un grupo arilo opcionalmente sustituido (el sustituyente o sustituyentes es de 1 a 3 grupos idénticos o diferentes seleccionados entre el grupo que consiste en un átomo de halógeno, un grupo alquilo C1-6, un grupo cicloalquilo C3-7, un grupo trifluorometilo, un grupo difluorometoxi, un grupo trifluorometoxi, un grupo ciano, un grupo alcoxi C1-6, un grupo cicloalcoxi C3-7, un grupo fenilo, un grupo alcoxicarbonilo C2-7, un grupo benciloxicarb
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