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2,3,5 TRISUBSTITUTED PYRROLE DERIVATIVES AS TOPOISOMERASE INHIBITORS AND THERAPEUTIC USES THEREOF
- 专利权人:
- 发明人:
- Ananda Hanumappa,Sharath Kumar Kothanahally S,Mahesh Hegde,Sathees C. Raghavan,Kanchugarakoppal S Rangappa
- 申请号：
- US15753888
- 公开号：
- US20180251425A1
- 申请日:
- 2016.02.26
- 申请国别(地区):
- US
- 年份:
- 2018
- 代理人:
- 摘要：
- The compounds of Formula (1) having topoisomerase inhibitory effect includeswherein, R1 is selected from a group consisting of H, OR5, optionally substituted C1-C12 alkyl, haloalkyl, C2-C12alkenyl, C2-C12alkynyl, C1-C12alkyloxy, C1-C12haloalkyloxy, C2-C10 heteroalkyl, C3-C12 cycloalkyl, C3-C12cycloalkenyl, C2-C12heterocycloalkyl, C2-C2 heterocycloalkenyl, C6-C18aryl, and C1-C18heteroarylR2, R3 and R4 are independently selected from a group consisting of H, halogen, CN, —NO2, SH, CF3, OH, CO2H, CONH2, OCF3, optionally substituted C1-C12alkyl, optionally substituted C1-C12haloalkyl optionally substituted C2-C12alkenyl, optionally substituted C2-C12alkynyl, optionally substituted C1-C12alkyloxy, optionally substituted C1-C12haloalkyloxy, optionally substituted C2-C12heteroalkyl, optionally substituted C3-C12cycloalkyl, optionally substituted C3-C12 cycloalkenyl, optionally substituted C2-C12 heterocycloalkyl, optionally substituted C2-C12 heterocycloalkenyl, optionally substituted C6-C18aryl, and optionally substituted C1-C18heteroarylR5 is selected H, optionally substituted C1-C12alkyl, optionally substituted C2-C12alkenyl, optionally substituted optionally substituted C1-C12 haloalkyl, optionally substituted C3-C12cycloalkyl, optionally substituted C6-C18aryl, and optionally substituted C1-Ci18heteroarylor a pharmaceutically acceptable salt, N-oxide, or prodrug thereof.
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- 中国工程科技知识中心
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- http://www.ckcest.cn/home/
