LUXEMBOURG INSTITUTE OF SCIENCE AND TECHNILOGY (LIST)
发明人:
Gaelle Corne,Jean-Sebastien Thomann
申请号：
US16478173
公开号：
US20190365660A1
申请日:
2018.01.17
申请国别(地区):
US
年份:
2019
代理人:
摘要：
A method for manufacturing supported lipid bilayer on a porous silica nanoparticle with a ζ-potential comprised between −；10 mV and +10 mV, the method comprising the steps of (a) providing a negatively charged supported lipid bilayer on a porous silica nanoparticle, wherein the negatively charged supported lipid bilayer has a ζ-potential inferior to −；15 mV and wherein the negatively charged supported lipid bilayer comprised at least one phospholipid and； (b) adding a formulation of lipids, the lipids being 1,2-dioleoyl-3-trimethylammonium-propane alias DOTAP, cholesterol and at least one lipid different from DOTAP and cholesterol. The method further comprises the step of (c) performing an ultra-sonication for promoting DOTAP incorporation. The method can be supplemented by the step of addition of alginate and the step of cross-linking the alginate. Also a nanocapsule and composition comprising the nanocapsule.
