The present invention provides a microneedle device comprising a substrate, a microneedle disposed on the substrate, and a coating layer formed on the microneedle, wherein the coating layer comprises a recombinant follicle stimulating hormone, arginine Wherein the mass of arginine in the coating layer is 0.07 to 0.75 times the mass of the recombinant follicle stimulating hormone and the mass of glycerin is in the range of 1 to 20 times the mass of recombinant follicle stimulating hormone 0.1 to 2.75 times the mass of the microneedle device.