A seeker device for facilitating access to a desired location within an ear, nose, throat or other location in a body may include a proximal shaft, an elastic distal portion, and an atraumatic distal tip. The elastic distal portion has a default shape with at least one curve to facilitate advancement of a distal end of the elastic distal portion through various anatomical passageways, toward the desired location. In some embodiments, the seeker device may be paired with a dilator device, to perform a dilation procedure on an anatomical structure in the ear, nose, throat or other part of the body. In other embodiments, the seeker device may be paired with a flexible endoscope, to facilitate visualization of an anatomical structure or area.