Methods and devices for providing a biopsy device with a modified handle and stylet that provides a vacuum to be delivered to the targeted tissue for removal. The vacuum may draw the tissue into the notch where the tissue may then be severed via the cannula. Alternatively, the tissue may be drawn into to the notch after being severed via the stylet and/or cannula. The vacuum may be used to bring a larger amount of tissue into the notch than would otherwise be brought in the notch if no vacuum was used, providing a larger sample through the same size access point.
