CECCARELLI, Simona M.,CONTE, Aurelia,KUEHNE, Holger,KUHN, Bernd,NEIDHART, Werner,OBST SANDER, Ulrike,RUDOLPH, Markus
申请号：
ES12780486
公开号：
ES2609773T3
申请日:
2012.10.29
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
Compounds of formula (I) ** Formula ** in which R 1 is alkyl, haloalkyl, cycloalkyl, haloalkoxy, cycloalkoxy, hydroxyalkyl, heterocycloalkyl, substituted heterocycloalkyl, substituted amino or substituted aminocarbonyl, in which substituted heterocycloalkyl is substituted with one to three substituents independently selected from oxo, halogen or alkyl, and in which the substituted amino and the substituted aminocarbonyl are substituted on the nitrogen atom with one to two substituents independently selected from alkyl, hydroxyalkyl and alkoxyalkyl, with the proviso that R1 is not methyl or ethyl； R2 is hydrogen, halogen, alkyl, haloalkyl, alkoxy or substituted amino, wherein the substituted amino is substituted on the nitrogen atom with one to two alkyl； R3 is hydrogen, alkoxy or halogen； R4 is hydrogen, halogen, alkyl, nitro or cyano； R5 is hydrogen； R6 is phenyl, substituted phenyl, pyridinyl or substituted pyridinyl, in which the substituted phenyl and the substituted pyridinyl are substituted with one to three substituents independently selected from alkyl, cycloalkyl, alkylcycloalkyl, cycloalkylalkyl, cycloalkylalkoxy, cycloalkylalkoxyalkyl, cycloalkoxyalkyl, cycloalkoxyalkyl, cycloalkoxyalkyl, cycloalkoxyalkyl, cycloalkoxyalkyl, cycloalkoxyalkyl, cycloalkoxyalkyl, cycloalkoxyalkyl, cycloalkyloxy halocycloalkyl, halocycloalkylalkyl, alkoxy, alkoxyalkoxy, alkoxyalkoxy, alkoxyalkoxyalkyl, hydroxyalkoalkyl, amino and substituted amino, wherein the substituted amino is substituted with one to two substituents independently selected from alkyl, cycloalkyl, haloalkyl, alkylcycloalkyl, cycloalkyl, alkylalkyl, alkylalkyl, alkylalkyl, alkylalkyl, alkylalkyl ； R7 is -COOH, tetrazol-5-yl, 3H- [1,3,4] oxadiazol-2-on-5-yl or 3H- [1,3,4] oxadiazol-2-thion-5-yl； n is zero or 1； with the proviso that at least one of R2, R3, R4 and R5 is different from hydrogen and that 6-methoxy-4-phenyl-2-trifluoromethylquinoline-3-carboxylic acid and 4- (3,4-dimethoxyphenyl acid ) -2-hydroxy
