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Recombinant swine influenza virus and uses thereof
专利权人:
UNIVERSITY OF SASKATCHEWAN
发明人:
ZHOU YAN,MASIC ALEKSANDAR
申请号:
NZ62027512
公开号:
NZ620275A
申请日:
2012.07.31
申请国别(地区):
NZ
年份:
2016
代理人:
摘要:
Disclosed is a recombinant, chimeric influenza A virus comprising eight segments, wherein said virus comprises more than one haemagglutinin (&ldquoHA&rdquo) segment (&ldquosegment 4&rdquo) from more than one influenza subtype, wherein said virus comprises segments 1-5, 7 and 8 from a porcine H1N1 influenza subtype and a second segment 4 from a porcine H3N2 influenza subtype, wherein the H3N2 segment 4 comprises neuraminidase (&ldquoNA&rdquo) packaging sequences from said H1N1 influenza subtype located 3&rsquo to said second segment 4, and further wherein all or a portion of the NA segment (&ldquosegment 6&rdquo) of the H1N1 influenza subtype is missing to render an attenuated virus. Also disclosed is a recombinant construct comprising: (a) a porcine influenza H3N2 subtype HA segment and (b) porcine influenza H1N1 subtype NA packaging sequences located 3&rsquo and 5&rsquo to said H3N2 HA segment, wherein the construct lacks all or a portion of the NA coding sequence of the H1N1 subtype.
来源网站:
中国工程科技知识中心
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