MÉTHODES D'UTILISATION DU FACTEUR DÉRIVÉ DE L'ÉPITHÉLIUM PIGMENTAIRE (PEDF) POUR LE TRAITEMENT OU LA PRÉVENTION DE LA TOXICITÉ GONADIQUE OU UTÉRINE INDUITE PAR UN AGENT
Ramot at Tel-Aviv University Ltd.;Mor Research Applications Ltd.
发明人:
申请号：
EP15774029.1
公开号：
EP3125924A4
申请日:
2015.03.30
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
A method of treating or preventing gonadal or uterine toxicity induced by an agent in a subject is provided. Accordingly there is provided a method comprising administering to a subject a therapeutically effective amount of pigment epithelium-derived factor (PEDF), thereby treating or preventing the gonadal toxicity induced by the agent. Also provided is, a method comprising determining gonadal function in a subject； and administering to the subject a therapeutically effective amount of PEDF, thereby treating or preventing the gonadal toxicity induced by the agent. Also provided is a PEDF for use in the treatment or prevention of gonadal toxicity induced by an agent in a subject. Also provided are cell culture, a medium, a kit and method for improving oocyte quality ex-vivo.
