RECOMBINANT NEWCASTLE DISEASE VIRUS COMPRISING A TRANSGENE ENCODING A FUSION PROTEIN COMPRISING A BINDING DOMAIN AND A HETEROLOGOUS DOMAIN COMPRISING AN ENZYME
BEIER, RUDOLF,PUHLER, FLORIAN,BOSSLET, KLAUS,WILLUDA, HANS JORG
申请号：
NZ59173305
公开号：
NZ591733A
申请日:
2005.11.10
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed is a recombinant oncolytic paramyxovirus comprising a nucleic acid with at least one transgene, wherein the nucleic acid of this transgene(s) codes for a binding protein that has a therapeutic activity when expressed by the virus-infected tumour cell and wherein the binding protein is a fusion protein comprising at least one binding domain and a heterologous domain comprising an enzyme； with the proviso that the binding protein is not an antibody molecule or a fragment or a derivative thereof.
