CASE WESTERN RESERVE UNIVERSITY;THE CLEVELAND CLINIC FOUNDATION
发明人:
SAMIA, ANNA CRISTINA S.,FRANGIAMORE, SALVATORE J.,HIGUERA RUEDA, CARLOS A.,KLIKA, ALISON K.,BARSOUM, WAEL K.
申请号：
CA3094360
公开号：
CA3094360A1
申请日:
2019.03.21
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
One aspect of the present disclosure can include a thermoresponsive nanocomposite for disrupting or preventing biofilm formation. The nanocomposite can include at least one polymer, one or more D-amino acids, and one or more energy-actuatable particles. The nanocomposite can have a first viscosity at about room temperature and, when exposed to about physiological temperature, obtains a second viscosity that is greater than the first viscosity. Application of energy to the nanocomposite from an energy source can excite the one or more energy-actuatable particles to cause localized heat release from the nanocomposite.
