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AMIDO TROPANE DERIVATIVES
专利权人:
发明人:
KOLCZEWSKI SABINE,PINARD EMMANUEL
申请号:
IN10564/CHENP/2012
公开号:
IN2012CN10564A
申请日:
2012.12.19
申请国别(地区):
IN
年份:
2014
代理人:
摘要:
The present invention relates to a compound of general formula (I) wherein R R and R are independently from each other hydrogen lower alkyl lower alkoxy cycloalkyl lower alkyl substituted by halogen or S lower alkyl or to a pharmaceutically acceptable acid addition salt to a racemic mixture or to its corresponding enantiomer and/or optical isomer thereof. It has been found that the compounds of general formula (I) are good inhibitors of the glycine transporter 1 (GlyT 1) and that they have a good selectivity to glycine transporter 2 (GlyT 2) inhibitors. The compounds may be used in the treatment of neurological and neuropsychiatric disorders.
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