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Amido-tropane derivatives
专利权人:
F. Hoffmann-La Roche AG
发明人:
Kolczewski, Sabine,Pinard, Emmanuel
申请号:
AU2011269145
公开号:
AU2011269145A1
申请日:
2011.06.17
申请国别(地区):
AU
年份:
2012
代理人:
摘要:
The present invention relates to a compound of general formula (I) wherein R, R and R are independently from each other hydrogen, lower alkyl, lower alkoxy, cycloalkyl, lower alkyl substituted by halogen or S-lower alkyl; or to a pharmaceutically acceptable acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer thereof. It has been found that the compounds of general formula (I) are good inhibitors of the glycine transporter 1 (GlyT-1), and that they have a good selectivity to glycine transporter 2 (GlyT-2) inhibitors. The compounds may be used in the treatment of neurological and neuropsychiatric disorders.
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