HSIN-ELL WANG,CHIH-YUAN LIN,WEI-TI KUO,CHUAN-LIN CHEN,MEI-HUI WANG,HUNG-MAN YU,MAO-CHI WENG,YU CHANG,WUU-JYH LIN
申请号：
US14247485
公开号：
US20140221639A1
申请日:
2014.04.08
申请国别(地区):
US
年份:
2014
代理人:
摘要：
A radiolabeled nucleoside analogue is provided, which includes radioactive iodine 123I/131I, and a nucleoside analogue selected from a group consisting of cytidine, thymidine, uridine, and a derivative thereof. A method for preparing the radiolabeled nucleoside analogue, and a use thereof are further provided. The nucleoside analogue, prepared through the preparation method with a short synthesis time and a high radiochemical yield, has a long in vivo physiological half life and a high stability in serum, and, as a radiopharmaceutical composition, is useful in development of tumor proliferation diagnosis or therapy prognosis evaluation, and further assists in observation of long-time in vivo metabolism of a drug.
