COOPER, MATTHEW,MILLER, DAVID,MACLEOD, ANGUS,THOM, STEPHEN,ST-GALLAY, STEPHEN,SHANNON, JONATHAN,STRUTT, IAN
申请号：
CA3078195
公开号：
CA3078195A1
申请日:
2018.11.09
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
The present invention relates to sulfonylureas and sulfonylthioureascomprising as-membered nitrogen-containing heteroaryl ring attached to thesulfonylgroup, wherein the heteroaryl ring is substituted with at least one groupcontainingan oxygen atom, and wherein said oxygen atom is attached to the heteroarylringvia at least two other atoms. The present invention further relates to salts,solvatesand prodrugs of such compounds, to pharmaceutical compositions comprising suchcompounds, and to the use of such compounds in the treatment and prevention ofmedical disorders and diseases, most especially by the inhibition of NLRP3.
