Systems and methods of imaging an organ of a patient include obtaining a plurality of two-dimensional (2D) tomosynthesis projection images of the organ. An x-ray image of the organ is obtained. A three-dimensional (3D) volume of the organ is reconstructed from the plurality of projection images and the x-ray image. A synthetic 2D image of the organ is generated from the plurality of projection images and the x-ray image. The x-ray image is mapped to the 3D volume. A user selection of an object of interest in the x-ray image or the synthetic 2D image is received. A plane through the 3D volume that crosses the selected object of interest is identified and displayed.
