Kyeong Soo Kim,Ki Young Jang,Seung Jae Park,Yong Il Kim,Jae Hyun Park,Jong Soo Woo
申请号：
US14345983
公开号：
US09220704B2
申请日:
2012.10.15
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to a hard capsule composite formulation comprising a capsule having a hemispherical closure at each end and an interior space and one or more tablets encapsulated in the capsule, wherein the tablet or the tablets as a whole have a shape conforming to the internal space of the capsule. The hard capsule composite formulation can efficiently charge pharmaceutical compositions inside the limited interior space of the capsule, and hence, it allows packing a high-dose of pharmaceutical composition in a relatively small-sized capsule, which increases productivity and patient compliance. Also, the composite formulation exhibits good dissolution rate because pharmaceutically active ingredients contained in the capsule are separated from one another, and thus, the ingredients are less affected by the dissolution rate of one another, allowing good storage stability which can optimize the therapeutic effects.
