A heterogeneous multiple core control system for predictive medical monitoring is provided. The system includes a first processor platform that is optimized for serialized computation and a second processor platform that is optimized for parallelized computation. A memory stores instructions that are executed by either the first processor platform or the second processor platform to provide the functionality of the system. By executing the instructions, the system determines whether a condition of a first patient is to be monitored using a primarily parallelized model or a primarily serialized model. The predicted condition is calculated using the primarily parallelized model by executing the primarily parallelized model on the second processor platform. The predicted condition is calculated using the primarily serialized model by executing the primarily serialized model on the first processor platform.