Disclosed is an image compression method of a digital pathology system. The image compression method is a method of compressing digital slide images having first to nth original plane images (n is a natural number greater than or equal to 2). The image compression method includes selecting a block having an optimal focal point as an optimal block from each set of blocks positioned at identical positions of the first to nth original plane images； forming one plane image as a virtual optimal plane image by combining only the optimal blocks； generating block descriptors for forming the first to nth original plane images based on the virtual optimal plane image； generating first to nth predictive plane images from the virtual optimal plane image such that the first to nth predictive plane images are the least out of focus by using location information for the blocks and the block descriptors； generating first to nth differential plane images, the first differential plane image corresponding to a difference between the first original plane image and the first predictive plane image and the nth differential plane image corresponding to a difference between the nth original plane image and the nth predictive plane image； and compressing the first to nth differential plane images.
