A touch-to-activate structure for make-up pen with function of vibration massage receives and contains therein a liquid and includes a container body, a base, a vibration device, a shielding lid, a cover, a leakage prevention valve, a contact massage lid, and a hold-down cap. The shielding lid possesses elasticity blocks external moisture, and supports the vibration device to provide a waterproof effect. The vibration device includes a spring conductor. The container body, the base, the shielding lid, and the cover are in communication with each other and the leakage prevention valve that has a valve hole is movably mounted in an opening of the cover, whereby when the contact massage lid is touched and pressed down, the leakage prevention valve is moved to press and push the spring conductor so as to automatically activate a vibration function of the vibration device and also to have the valve hole shielded.
