ДИМАРЧИ Ричард Д. (US),ХОФФМАНН Айке (DE),КОПЕЦКИ Эрхард (DE),РЮТ Маттиас (DE),ТИФЕНТАЛЕР Георг (DE)
申请号：
RU2015101699
公开号：
RU2015101699A
申请日:
2013.06.18
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. The Fc region fusion polypeptide or Fc region conjugate comprising one, two, three, or four naturally occurring or synthetic incretin receptor ligand polypeptides, each of which is covalently linked to the Fc region, the fusion polypeptide or conjugate comprising the sequence amino acids LPXTG (SEQ ID NO: 75), optionally LPETG (SEQ ID NO: 74) .2. A Fc region fusion polypeptide or Fc region conjugate according to claim 1, comprising the amino acid sequence LPETG (SEQ ID NO: 74) between the amino acid sequence of the incretin receptor ligand polypeptide and the amino acid sequence of the Fc region. The Fc region fusion polypeptide or Fc region conjugate of claim 2, comprising Gly-Gly or Gly-Gly-Ser or Gly-Gly-Gly, Gly-Gly-Gly-Ser (SEQ ID NO: 88), Gly-Gly -Gly-Gly (SEQ ID NO: 85), or Gly-Gly-Gly-Gly-Ser (SEQ ID NO: 90), attached C-terminally to LPETG (SEQ ID NO: 74). 4. The Fc region fusion polypeptide or Fc region conjugate according to claim 3, comprising (GGGS), where n = 1-6 (SEQ ID NO: 57-60, 88 and 89), (GGGGS), where m = 1-6 (SEQ ID NO: 61-64, 90 and 91), or (GGGGGS), where o = l-6 (SEQ ID NO: 65-67 and 92-94) .5. The Fc region fusion polypeptide or Fc region conjugate of claim 4, comprising any of SEQ ID NOs: 57-67.6. The Fc region fusion polypeptide or Fc region conjugate according to claim 1, comprising Gly or Gly-Gly attached N-terminally to LPXTG (SEQ ID NO: 75). 7. The Fc region fusion polypeptide or Fc region conjugate of claim 1, wherein the Fc region is a human Fc region with a mutation of an amino acid residue at position 329 and at least one additional mutation of at least one amino acid selected from a group comprising amino acid residues at position 228, 233, 234, 235, 236, 237, 297, 318, 320, 322 and 331, in another residue, and the residues in the Fc region are numbered in accordance with the EU Kabat index. 8. The Fc region fusion polypeptide or Fc region conjugate according to claim 1, characterized in that the variant human Fc region has a r
