Horn, Carsten,Zollner, Sabine,Metzner, Hubert,Schulte, Stefan
申请号：
AU2012318292
公开号：
AU2012318292A1
申请日:
2012.10.18
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
#$%^&*AU2012318292A120130502.pdf#####CSL BEHRING GMBH 2011_M008_A186 HAU/kk 18.10.2012 5 Abstract The present invention relates to a method for increasing the stability of a Factor VIII molecule after purification, lyophilization and reconstitution, comprising preventing proteolytic cleavage of the Factor VIII molecule into a first fragment comprising 10 essentially the Al domain and the A2 domain and a second fragment comprising essentially the A3 domain, the C1 domain and the C2 domain throughout manufacturing of the Factor VIII molecule. The invention further pertains to a method for improving the bioavailability of Factor VIII after intravenous and nonintravenous injection.
