A surgical instrument comprises a housing. A pair of tissue manipulating jaws extend distally from the housing. The jaws have an opened position and a closed position. A driver is slideably positioned in the housing and operatively connected to the jaws. The driver has a tissue piercing end projecting proximally from the housing. A percutaneous instrument comprises inner and outer coaxial shafts each having a proximal end and a distal end. An actuator is connected to the proximal ends of the coaxial shafts. Mating features on the distal ends of the coaxial shafts are adapted to engage the driver and housing. A loader comprises an elongate shaft having a proximal end and a distal end. An actuator is attached to the proximal end of the loader elongate shaft. A tube on the distal end of the loader shaft is adapted to releasably hold the end effector.
