Medical systems and devices are provided for engaging tissue (T), e.g. for clipping tissue (T), closing a perforation or performing hemostasis. Generally, the medical system (20) including a housing (42), first (44) and second (46) jaws rotatable relative to the housing (42), a driver (48), and an elongate drive wire (22). The elongate drive wire (22) may be disconnected from the driver (48), first (44) and second (46) jaws, and the housing (42), which are left in vivo engaged with the tissue (T).
