Marcus E. Peter,William E. Putzbach,Andrea E. Murmann,Monal Patel,Quan Gao
申请号：
US15900392
公开号：
US20180320187A1
申请日:
2018.02.20
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Disclosed are polynucleotides, compositions, and methods related to RNA interference (RNAi). The disclosed polynucleotides, compositions, and methods may be utilized for treating diseases and disorders through RNAi. Particular disclosed are toxic RNAi active seed sequences and methods of using toxic RNAi active sequences for killing cancer cells. The disclosed toxic RNAi active seed sequences preferentially target and inhibit the expression of multiple essential genes for cell survival and/or growth through a process called “death-induced by survival gene elimination” or “DISE.”
