TAGALAKIS, Aristides,HART, Stephen,KRISTIANSEN, Are,DESSEN, Arne,RYE, Philip
申请号：
EPEP2019/056890
公开号：
WO2019/180047A1
申请日:
2019.03.19
申请国别(地区):
EP
年份:
2019
代理人:
摘要：
The invention provides methods for translocating micro/nanoparticles and molecules or interest carried thereby across mucus layers. More specifically there is provided a method for translocating a cationic micro/nanoparticle across a mucus layer said method comprising (a) contacting the mucus layer with at least one alginate oligomer, said alginate oligomer having at least 70% mannuronate residues, together with the cationic micro/nanoparticle； or (b)(i) contacting the cationic micro/nanoparticle with an alginate oligomer having at least 70% mannuronate residues thereby forming a micro/nanoparticle carrying said alginate oligomer, and (b)(ii) contacting the mucus layer with the micro/nanoparticle prepared in step (b)(i). There is also provided a method for translocating a molecule of interest across a mucus layer said method comprising contacting the mucus layer with a micro/nanoparticle which is formed of self-assembling micro/nanoparticle forming components, wherein at least one is a cationic micro/nanoparticle forming agent and at least one is an alginate oligomer which has at least 70% mannuronate residues, and further comprises said molecule of interest, optionally wherein the molecule of interest is covalently bound to one or more of the self-assembling micro/nanoparticle forming components. The invention further relates to the use of alginate oligomers in the methods of the invention and to micro/nanoparticles of the invention.L'invention concerne des procédés de translocation de micro/nanoparticules et de molécules d'intérêt portées par celles-ci à travers des couches de mucus. Plus spécifiquement, l'invention concerne un procédé de translocation d'une micro/nanoparticule cationique à travers une couche de mucus, où ledit procédé comprend (a) la mise en contact de la couche de mucus avec au moins un oligomère d'alginate, ledit oligomère d'alginate contenant au moins 70 % de résidus mannuronate, et la micro/nanoparticule cationique ； ou (b) (i) la mise en con
