Jose Enrique Montero Casimiro;Agustin Bienvenido Lage Davila;Rolando Perez Rodriguez
发明人:
Jose Enrique Montero Casimiro,Rolando Perez Rodriguez,Agustin Bienvenido Lage Davila
申请号：
US10309015
公开号：
US08563003B2
申请日:
2002.12.04
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention relates to methods of treatment useful in chronic diseases, by means of the rupture of tolerance to self-antigens and increasing autoimmune response against these antigens. More particularly, the present invention relates to methods useful in the treatment of tumors that are growth dependent on the Epidermal Growth Factor, including non-small cell lung carcinoma.In the present invention a therapeutic combination is revealed that includes the combination of a vaccine against self antigens with a monoclonal antibody against peripheral T cells or a chemotherapeutic drug able to induce a depletion of peripheral T cells.In another one of its aspects the present invention reveals a method of treatment of chronic diseases in which the rupture of the tolerance to self antigens is essential for the control of the disease, this method includes the administration of a immune suppressor agent between two cycles of vaccination against a self antigen, which could be for example the EGF, being this scheme of effective treatment for the reduction of tumors whose growth depends on EGF.
