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MOLECULES DE CHARPENTE A BASE DE FIBRONECTINE STABILISEE
专利权人:
BRISTOL-MYERS SQUIBB COMPANY
发明人:
LIPOVSEK, DASA
申请号:
CA2943228
公开号:
CA2943228A1
申请日:
2015.03.19
申请国别(地区):
CA
年份:
2015
代理人:
摘要:
Provided herein are proteins comprising a fibronectin based scaffold (FBS) domain, e.g., 10Fn3 molecules, that bind specifically to a target, and wherein the FBS domain is linked at its C-terminus to a region consisting of PmXn, wherein P is proline, X is any amino acid and wherein n is 0 or an integer that is at least 1 and m is an integer that is at least 1, and wherein the PmXn moiety provides an enhanced property to the FBS domain, e.g., enhanced stability, relative to the protein that is not linked to the PmXn moiety.
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