The invention relates to the technical field of Chinese herbal preparations, specifically to a preparation method for a wall-broken dendrobium preparation. The preparation method for the wall-broken dendrobium preparation comprises the following steps: crushing dendrobium into wall-broken powder then carrying out ethanol-water wet granulation by controlling the mass of an ethanol solution and the wall-broken powder carrying out extrusion forming at a certain rotating speed and then carrying out drying. The preparation method has a high granulation rate and the prepared wall-broken dendrobium preparation has high bioavailability, good stability and good disintegration performance.
