CHUNG-ANG UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
发明人:
CHOI, Young Wook,최영욱,LEE, Sang Gon,이상곤,KANG, Jongbu,강종부
申请号：
KRKR2015/011444
公开号：
WO2016/108413A1
申请日:
2015.10.28
申请国别(地区):
WO
年份:
2016
代理人:
摘要：
The present invention relates to a formulation for external application to the skin of tacrolimus, which is a poorly soluble drug used as a second therapeutic agent for atopic dermatitis and, more specifically, to a composition of a hydrophilic external gel formulation capable of enhancing skin permeability of tacrolimus, and a preparation method therefor. The hydrophilic external gel formulation loaded with tacrolimus of the present invention is in an easily preparable practical form with excellent moisturizing performance, and is excellent in spreadability and has improved drug delivery, skin permeability and skin residual capacity when applied to the skin, compared to conventional ointments, and thus can be usefully used for the treatment of atopic dermatitis and other immune diseases.La présente invention concerne une formulation destinée à lapplication externe sur la peau du tacrolimus qui est un médicament faiblement soluble utilisé comme second agent thérapeutique pour la dermatite atopique et, plus particulièrement, une composition dune formulation de gel externe hydrophile pouvant améliorer la perméabilité cutanée du tacrolimus, et un procédé de préparation associé. La formulation de gel externe hydrophile chargée du tacrolimus, de la présente invention, se présente sous une forme pratique pouvant être préparée facilement et dotée dune excellente performance dhydratation, dune excellente aptitude à létalement et améliore ladministration du médicament, la perméabilité cutanée et la capacité résiduelle cutanée lorsquelle est appliquée sur la peau, comparée à des onguents traditionnels, et peut ainsi être utilisée avantageusement dans le traitement de la dermatite atopique et dautres maladies immunitaires.본 발명은 아토피 피부염의 2차 치료제로 사용되는 난용성 약물인 타크로리무스의 피부 외용제의 제형에 관한 것으로서, 보다 구체적으로는 타크로리무스의 피부투과능을 증진시킨 친수성 외용 겔 제제의 조성 및 제조 방법에 관한 것이다. 본 발명의 타크로리무스를 탑재한 친수성 외용 겔 제제는 쉽게 제조할 수 있는 수분 보습능력이 뛰어난 실용적인 제형으로 기존의 연고제에 비해 피부 도포시 전연성이 우수하고 향상된 약물전달과 피부 투과능, 피부 잔류 능력을 가짐으로써 아토
