INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE;UNIVERSITE PARIS-SUD XI;ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS
发明人:
Antoine Durrbach,Hanz Lorenzo,Severine Beaudreuil
申请号：
US14402539
公开号：
US20150140010A1
申请日:
2013.05.22
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to methods for diagnosing and treating focal segmental glomerulosclerosis. More particularly, the present invention relates to a method for determining whether a subject is at risk of having or developing a focal segmental glomerulosclerosis (FSGS) comprising the step consisting of determining the level of calcium/calmodulin-dependent serine protein kinase (CASK) in a blood sample obtained from the subject. The present invention also relates to an agent effective to inhibit the binding of CASK to hCD98 present on the surface of podocytes for use in the prevention or treatment of focal segmental glomerulosclerosis (FSGS) in a subject in need thereof.
