PROCEDES ET COMPOSITIONS POUR TRAITER DES TROUBLES A L'AIDE DE POLYPEPTIDES DE FOLLISTATINE

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专利权人:

INC.;ACCELERON PHARMA

发明人:

KUMAR, RAVINDRA,GRINBERG, ASYA

申请号：

CA2950754

公开号：

CA2950754A1

申请日:

2015.06.04

申请国别(地区):

CA

年份:

2015

代理人:

摘要：

The present invention relates to follistatin-Fc fusion proteins that have effects in the tissue of administration (such as an injected muscle), rather than systemic effects. The Fc domain results in dimerization of the follistatin-Fc fusion protein, and provides enhanced tissue retention. The description includes fusion proteins comprising a human follistatin polypeptide consisting of FST288, FST291 (a non-natural truncated follistatin) or FST315； and a human IgGl or IgG2 Fc domain.

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