The present invention relates to a method for the prevention and/or treatment of depression. The method according to the invention comprises the oral administration of a preparation which contains at least the following fractions:a) long chain polyunsaturated fatty acids；b) at least two different phospholipids selected from the group consisting of phosphatidyl-serine, phosphatidylinositol, phosphatidylcholine and phosphatidylethanolamine andc) one or more compounds which are a factor in methionine metabolism, which compounds are selected from the group consisting of folate, vitamin B12, vitamin B6, magnesium and zinc or equivalents thereof.
