THUNUGUNTLA, SIVA SANJEEVA RAO,HOSAHALLI, SUBRAMANYA,PANIGRAHI, SUNIL KUMAR,SCHWARZ, MATTHIAS,ARLT, MICHAEL
申请号：
CA3053068
公开号：
CA3053068A1
申请日:
2018.02.23
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present invention provides 1, 4, 6-trisubstituted-2-alkyl-1H-benzo[d]imidazole derivatives as dihydroorotate oxygenase inhibitor compounds of formula (I), which may be therapeutically useful as DHODH inhibitors, in which R1 to R3 and 'm' have the meanings given in the specification, and pharmaceutically acceptable salts or stereoisomer thereof that are useful in the treatment and prevention in diseases or disorder, in particular their use in diseases or disorder where there is an advantage in inhibiting DHODH. The present invention also provides methods for synthesizing 1, 4, 6-trisubstituted-2-alkyl-1H-benzo[d]imidazole derivatives of formula (I). The present invention also provides pharmaceutical formulations comprising at least one of the DHODH inhibitor compound of formula (I) together with a pharmaceutically acceptable carrier, diluent or excipient.
