The present invention relates to conditions such as hyperglycemia, as well as diabetes, autism, fibromyalgia, inflammatory bowel disease (IBD), graft versus host disease (GVHD), HIV / AIDS, multiple organ dysfunction syndrome, hypersensitivity Intestinal Syndrome (IBS), childhood steatosis, eczema, psoriasis, acute pancreatitis, Parkinson's disease, depression, chronic fatigue syndrome, asthma, multiple sclerosis, arthritis, ankylosing spondylitis, nonalcoholic fatty liver disease, Methods, compositions, and kits are provided for treating in subjects in need of treatment for increased intestinal permeability, including underlying diseases such as alcoholic cirrhosis, environmental enteropathy, or quasi-orcol. [Selection figure] None本発明は、高血糖症等の状態、ならびに糖尿病、自閉症、線維筋痛症、炎症性腸疾患（ＩＢＤ）、移植片対宿主病（ＧＶＨＤ）、ＨＩＶ／ＡＩＤＳ、多臓器不全症候群、過敏性腸症候群（ＩＢＳ）、小児脂肪便症、湿疹、乾癬、急性膵炎、パーキンソン病、鬱病、慢性疲労症候群、喘息、多発性硬化症、関節炎、強直性脊椎炎、非アルコール性脂肪性肝疾患、アルコール性肝硬変、環境性腸症、またはクワシオルコル等の基礎疾患を含む、腸透過性亢進の治療を必要とする対象においてそれを治療するための方法、組成物、及びキットを提供する。【選択図】なし
