移植片対宿主病(GVHD)モデル動物
- 专利权人:
- 独立行政法人科学技術振興機構
- 发明人:
- 高井 俊行,中村 晃
- 申请号：
- JP2004100061
- 公开号：
- JP5242882B2
- 申请日:
- 2004.03.30
- 申请国别(地区):
- JP
- 年份:
- 2013
- 代理人:
- 摘要：
PROBLEM TO BE SOLVED: To provide a model animal developing a fatal graft versus host disease (GVHD), a screening method for a preventing and treating agent of the GVHD by using such the GVHD model animal, a receptor protein PIR-B and its gene recognizing a MHC class I molecule, and a preventing and treating agent of the GVHD by using a human homolog of the PIR-B as an active ingredient.
SOLUTION: This method for screening the preventing and treating agent of the GVHD by using a mouse losing a function of expressing the PIR-B by an inactivation with a gene mutation such as destruction, delete, substitution, etc., of the whole or part of an endogenous gene of a non-human animal encoding the PIR-B, as the GVHD model animal. As the human homolog of the PIR-B, an LILRB1, LILRB2, etc., can be mentioned.
COPYRIGHT: (C)2006,JPO&NCIPI
- 来源网站：
- 中国工程科技知识中心
